In his native Haiti, he served as the Rector of the Mayor Seminary School of Philosophy; and the Mayor Seminary School of Theology of Haiti affiliated to the Pontifical University URBANIANA of Rome. He became the Dean of Studies at the Faculty of Theology of the Mayor Seminary of Port-au-Prince.
From 1997 to the year 2003, while working on a doctoral dissertation in Biblical Studies at the Catholic University of America (CUA) of Washington DC, he was appointed the Director of the Haitian Ministry in the Archdiocese of Washington and ministered to the Haitian Community of the Greater Washington DC Area, including part of Maryland and Northern Virginia. During his stay in the City Capital, he taught New Testament studies at the Washington Theological Union, until he was called back home to Haiti in September 2003.
From July 2003 to March 2009, he served as the Secretary of the Catholic Bishop Conference of Haiti and the spokesperson for the Roman Catholic Church in the country, the voice of the Bishop Conference of Haiti.
In 2004, Pope John Paul II named Father Pierre-André PIERRE, Chaplain of His Holiness, bestowing on him the title of Monsignor. From the year 2004 until 2009, Monsignor Pierre-André PIERRE, worked also as the Pastor of the Parish of “Sacré Coeur de Turgeau”.
On February 6, 2009, Monsignor Pierre-André PIERRE was elected by the Catholic Bishop Conference of Haiti as the President of the Catholic University of Haiti “Université Notre-Dame d’Haiti, (UNDH),” which he presents, for the youth, the families and the country, as a token towards building a new society in Haiti.